Glucosamine is a molecule that plays a vital role in joints. Glucosamine sulfate is a naturally occurring substance found in the body and is present in the fluid that surrounds the joints. It participates in the formation of articular cartilage, whose structure contributes to the mobility and protection of the joints. Although the body has the capacity to synthesize glucosamine, the rate of this molecule tends to decrease with age, therefore, to maintain joint condition, supplementation is recommended. Glucosamine is considered the main precursor of glycosaminoglycans. By coming together, these molecules form the proteoglycans present in cartilage. Glucosamine plays a key role in the joints by contributing to their protection and mobility. Several studies have confirmed the antioxidant power of glucosamine. This activity helps protect cells against oxidative stress and fight damage caused by free radicals. The anti-inflammatory activity of glucosamine has also been the subject of several scientific studies. Glucosamine supplementation aids in a decrease in various markers of inflammation. Glucosamine plays a vital role in the joints, by stimulating the synthesis or regeneration of cartilage. Beyond glucosamine's essential role in cartilage, its anti-inflammatory activity also helps relieve joint pain and fight certain joint diseases. Among the benefits assigned to glucosamine are keeping joints in good condition, reducing pain in cases of osteoarthritis, improving mobility and improving elasticity. Most research shows that taking glucosamine sulfate by mouth may provide some pain relief in people with osteoarthritis, especially those with osteoarthritis of the knee.